Blebs; the telltale signs of diseased and damaged lungs, have long indicated the point of irreparable parenchymal destruction producing the stereotypical signs and symptoms of late stage COPD. But the blebu2019s days may be numbered.
According to snippet in the RC Currents section of the May issue of the AARC Times, Johnu2019s Hopkins researchers noted, u201cusing hepatocyte growth factor (HGF)u2026 have made progress in regrowing alveoli and restoring lung structure in mice genetically engineered to develop a human-like form of emphysema.u201d
The investigators found that u201cmice with emphysema who received HGF developed a 17 percent improvement in the size of their air sacs compared to placebo-treated mice, consistent with improved lung structure and function.u201d Additionally, u201cThe HGF also prevented destruction of the alveoli by reducing the oxidative stress that contributes to lung injury.u201d
Not to u2018count the alveoli before theyu2019re hatchedu2019 but perhaps, in the future, inhaled restorative therapies, like HGF, will accompany conventional and rehabilitative regimens. It would result in healing, not just symptomatic relief, but overall improve lung function and quality of life!
Blebs and eventually COPD will be a thing of the past!