Recorded Webinar with Dr. Curtis Cetrulo: Stem Cells and Immunologic Tolerance Induction for Hand and Face Transplantation
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Watch the recorded webinar to hear Dr. Curtis Cetrulo, Reconstructive Plastic Surgeon and Stem Cell Researcher from Massachusetts’s General Hospital, speak about the amazing advancements surrounding transplanted limbs and reconstructive cosmetic surgeries using stem cells.
Various stem cell types are currently under investigation for an exciting new application- the induction of immunologic tolerance of hand and face transplants. Hand and face transplants have revolutionized reconstructive surgery, but recipients still must take lifelong immunosuppressive medications, which confer risks of infection and malignancy. Immunologic tolerance would eliminate the need for these drugs. Stem cells from various sources, including cord blood, may play an important role in tolerance induction for hand and face transplant patients.
You will learn:
- The long-term risks of immunosuppressive medications
- How immunologic tolerance can eliminate these medications
- How stem cells are critical to the process of obtaining immunologic tolerance.
Dr. Curtis Cetrulo, Jr., M.D., FACS, FAAP, helps you understand these hand and face transplantations and the exciting new paradigm in reconstructive surgery.
Dr. Curtis Cetrulo is the Senior Investigator and Head of the Vascularized Composite Tissue Allotransplantation Laboratory at the Transplantation Biology Research Center, Massachusetts General Hospital graduated from Stanford University in 1992 and Tufts University School of Medicine in 1999. Following completion of plastic surgery residency training, Dr. Cetrulo practiced reconstructive microsurgery and hand surgery at the University of Southern California Medical Center and the Shriners Hospital or Children-Los Angeles where he performed pediatric reconstructive microsurgery, burn reconstruction, cleft lip and palate surgery, and pediatric hand surgery. In 2009, Dr. Cetrulo joined the Division of Plastic and Reconstructive Surgery of the Massachusetts General Hospital and the staff of Shriners Hospital for Children-Boston. His laboratory is investigating tolerance induction strategies for vascularized composite tissue allografts (VCA) in the immunogenetically-defined MGH miniature swine model. Current research efforts are directed toward use of genetically-modified porcine xenografts for the treatment of burns; establishing mixed hematopoietic chimerism to induce transplantation tolerance o VCA in swine and toward exploring the immunologic mechanisms involved in tolerance and rejection of the skin component of VCA in swine.
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