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Platelet-Rich Plasma

Platelet-Rich Plasma: My View from the Transfusion Service Platelets play a significant role in primary hemostasis, however they also serve as a reservoir of a number of important growth factors, including but not limited to platelet-derived growth factor (PDGF), vascular…


Avoid Sample Rejections

Avoid Sample Rejections Due to Hemolysis Definition: Hemolysis involves breakage of red blood cell (RBC) membrane which causes the release of hemoglobin and other internal components into the surrounding fluid (Plasma). Hemolysis is a widely documented issue for blood samples…


The Transfusion Indication Threshold Study

Commentary: THE TRANSFUSION INDICATION THRESHOLD (TITRe) STUDY Murphy et al. N Engl J Med 2015; 372:997-1008 In the wake of the recently published TITRe study, SHG received numerous queries as to whether this trial casts doubt upon restrictive transfusion practices…


Chronic Kidney Disease

Chronic Kidney Disease: Better Care = Better Outcomes Chronic kidney disease (CKD) is a global health problem.  In the United States, the incidence and prevalence is rising.  CKD results in poor health outcomes, is often associated with and/or caused by…


Hematology and Oncology Blood Management Issues

Issues for Blood Management in Hematology/Oncology Hematology/Oncology patients comprise a unique subpopulation for whom transfusion therapy is often necessary in both the acute care setting as well as for long-term support. Red blood cells (RBCs) and platelets are the most…


Packed Red Blood Cell Transfusions

Packed Red Blood Cell Transfusions and Health Care Associated Infections Rohde J et al.  Health care-associated infection after red blood cell transfusion: A systematic review and meta-analysis. JAMA 2014; 311: 1317-1326 Transfusion of blood products is the most common procedure…


The Rise of Designer Blood Products

The Rise of Designer Blood Products 4 Factor PCCs Blood factor concentrates are not new, but most U.S. physicians are only vaguely familiar with them.  Single or multiple blood factor concentrates were originally developed to treat patients with congenital clotting…


Premedication for Prevention of Transfusion Reactions

Premedication for Prevention of Transfusion Reactions – A Practice Without Evidence Febrile non-hemolytic (FNHTR) and allergic transfusion (ATR) reactions have historically been reported to occur in up to 30% of transfusions, however with the use of leukoreduction and single-donor apheresis…


Stewardship of Blood

Stewardship: Waste Not, Want Not A publication in the upcoming Transfusion journal reports on a successful and practical initiative to reduce blood component wastage via a targeted team approach surrounding blood transport and storage. 1 The national wastage rate for…


Transfusion in Sepsis

Transfusion in Sepsis – The Controversy Continues Red blood cell (RBC) transfusion in septic patients remains a controversial topic. The well-known and often quoted article by Rivers et al. in New England Journal of Medicine, 2001, was one of the…